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The crude extract of Aster bakerianus roots used for treatment of a variety of ailments in Lesotho was evaluated for anti-inflammatory activity and phytochemical content. Extract was first tested for toxicity at oral dosages of 0 (negative control), 1000, 2000, 3000 and 5000 mg/kg bw with five groups of female mice, each group having four mice. Negative control group received sterile distilled water (1.0 ml/kg bw). Mice were observed for general symptoms of toxicity for 24 hours and left for a further 14 days for any delayed toxicity. None of the extract doses induced toxicity. Anti-inflammatory activity of A. bakerianus was determined using the carrageenan-induced rat paw oedema assay. Five groups of six mice each were orally pre-treated as follows: Negative control group (group 1) received sterile distilled water (1.0 ml/kg bw). Positive control group (group 2) received indomethacin (10mg/kg bw). Three test groups (group 3, 4 and 5) received A. bakerianus extract, 100, 200 and 400 mg/kg bw respectively. After one hour of pre-treatment, all test groups and controls were injected with 0.1 ml carrageenan subcutaneously in the right hind paw and paw thicknesses recorded at the following time intervals: 0, 1, 2, 3, 4, 5, 6, and 24 hours. Statistically (p

Evaluation of Aster bakerianus Burtt Davy ex C.A. Sm. Crude Root Extract for Acute Antiinflammatory Activity in Rats