English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background. Periodontal disease iswidespread disease. Therefore, the problem of diagnosis of these diseases remains relevant. This study is devoted to the study of the cytokine status of oral fluid and changes in buccal epithelium in patients with chronic generalized periodontitis (CGP). Objectives ― the clinical and diagnostic efficiency of oral fluid and buccal epithelium in the detection of the initial stages of CGP. Methodology. The 23 healthy volunteers and 62 patients with CGP were examined. Clinical and laboratory study included determination of interleukin concentration (IL): IL-2, -4, -6, -17.There was also an analysis buckling cytograms to detect cytoplasmic,karyological and mixed anomalies. . Results. The data obtained indicate a cytokine disbalance (change in the IL-2/IL-4 ratio). Serum IL-4 is a sensitive and specific indicator of the inflammatory process activity (diagnostic sensitivity 88  %, diagnostic specificity – 95  %). The content of IL-6 and IL-17 in the oral fluid did not change significantly with mild CGP. The accumulation of cytological abnormalities (micronuclei) and an increase in the level of cells with degenerative-dystrophic changes in the nucleus and apoptotic bodies in patients with CGP were noted. The greatest diagnostic value of these indicators was in the detection of early manifestations of CGP. Conclusions. The progress of chronic generalized periodontitis is accompanied by the disturbance of local mechanisms of immunoreactivity, the evaluation of which can become a reliable research and diagnostic tools. Determination of the IL-4 concentration and the number of cells in apoptosis is quite access, non-invasive and economical type of labotatory tests. These indicators, as established in the study, can be considered sensitive markers of chronic periodontitis of mild severity.

PATHOGENETIC JUSTIFICATION OF NEW APPROACHES TO THE ASSESSMENT OF THE STATE OF ORAL CAVITY IN CHRONIC GENERALIZED PARODONTITIS