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Jelatin Doku Iskelesinin Mekanik Ozellikleri Uzerine Gozenek Olusturucu Ajanin Boyutu ve Baglanti Suresinin Etkileri Bu calismada, makrogozenekli ve gozenekleri birbirleri ile baglantili olarak kaliplama, isi etkili faz ayrimi ve tanecik uzaklastirma yontemleri ile uretilen jelatin bazli doku iskelelerinde gozenek olusturucu ajan olan parafin kurelerin boyutu ve baglanti surelerinin doku iskelelerinin mekanik ozellikleri uzerine olan etkileri incelenmistir. Sunger formlu ve acik hucreli yapida olan doku iskelelerinin mekanik ozellikleri sikistirma testi ile olculmustur. Yapilan olcumler parafin kure capindaki artisin doku iskelelerinin sikistirma katsayisini istatistiksel olarak anlamli bir sekilde etkilemedigini gostermistir. Ancak, parafin kurelerin maruz birakildigi isi etkilesim suresinin 100 dakikadan 400 dakikaya arttirilmasinin 250-425 µm capindaki parafin kurelerle hazirlanan doku iskelesinin elastisite degerini arttirdigi belirlenmistir (p<0.05). Ayrica, 425-600 μm capindaki parafin kurelerle hazirlanan doku iskelelerinde, isi etkilesim suresi 100 dakikadan 400 dakikaya arttirildiginda sikistirma katsayisi anlamli bir sekilde azalmistir (p<0.05). Elde edilen sonuclar, bu tur doku iskelelerinde parafin kurelerin boyutundan cok baglanti suresinin mekanik ozellikler uzerinde etkili oldugunu gostermistir.  The Effects of Porogen Agent Size and Interconnection Time on the Mechanical Properties of Gelatin Scaffold In this study, the effects of particle size and interconnection time of porogen agent paraffin spheres on the mechanical properties of macroporous and interconnected scaffolds prepared with combination of molding, phase separation and particle leaching methods were investigated. The mechanical properties of the open-cell foam type scaffolds were measured with a compressive test. It was determined that the increase in the size of paraffin spheres did not significantly change the compressive modulus of the scaffolds. On the other hand, elasticity of the scaffold prepared from 250-425 µm sized paraffin spheres increased significantly (p<0.05) by extending incubation time from 100 to 400 minutes. Morever, elastisity of the scaffold prepared from 425-600 µm sized paraffin spheres decreased significantly (p<0.05) by extending incubation time from 100 to 400 minutes. The results indicated that in this type of scaffold, interconnection time of paraffin spheres has a stronger influence on the compressive modulus of scaffolds than the size of paraffin spheres.

celal bayar üniversitesi fen bilimleri dergisi

Jelatin Doku İskelesinin Mekanik Özellikleri Üzerine Gözenek Oluşturucu Ajanın Boyutu ve Bağlantı Süresinin Etkileri - The Effects of Porogen Agent Size and Interconnection Time on the Mechanical Properties of Gelatin Scaffold