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The article presents some data of the xanthine metabolism violations study in patients with chronic heart failure and concomitant chronic kidney disease at different stages. The study demonstrates a significant increase in xanthine oxidase activity, that confirms changes of metabolism towards oxidase pathway of uric acid in patients with chronic heart failure with concomitant chronic kidney disease. The negative impact of xanthine metabolism violations on the clinical course and progression of heart failure functional class was demonstrated. Thus in patients with CHF and CKD the progression of functional class and decrease in the left ventricular ejection fraction was associated with increased xanthine oxidase activity, while in patients without concomitant CKD it was associated only with increased serum uric acid levels. The obtained results also show the important role of xanthine oxidase system in the impaired kidney function.

XANTHINE METABOLISM IN THE PROGRESSION OF CHRONIC HEART FAILURE: FEATURES OF DISORDERS IN PATIENTS WITH CONCOMITANT CHRONIC KIDNEY DISEASE