STUDY OF CHANGES IN COAGULATION PROFILE OF PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY USING CARBON DIOXIDE PNEUMOPERITONEUM

BACKGROUND: Laparoscopic cholecystectomy is a common surgical procedure and carbon dioxide pneumoperitoneum created for this purpose may alter the coagulation profile of these patients. This study aims to find the effects of carbon dioxide pneumoperitoneum on coagulation profile and assess if there is an increased risk of thrombosis. MATERIALS AND METHODS: A clinical observational study was conducted with 50 patients who underwent laparoscopic cholecystectomy using carbon di oxide pneumoperitoneum. The prothrombin time and D-dimer values were calculated before and after surgery .using the paired t test data was analyzed. RESULTS: The study showed a decrease in the prothrombin time and increase in the D-dimer value post operatively. The mean of prothrombin time after surgery was 0.13 seconds lower than the preoperative value and D-dimer was found to be elevated three times the pre operative values. The p value calculated for both were highly significant. CONCLUSION: Laparoscopic cholecystectomy using carbon dioxide pneumoperitoneum leads to hypercoagulable states. Hence stringent measures need to be taken to put the patient on prophylaxis for deep vein thrombosis to avoid dire consequences.