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S AND PRESENTATIONS Oral Presentations: National/International Meetings 1. Royal J, Baldauf K, Kouokam J, Matoba N. “Plant-made cholera toxin B subunit as a candidate oral immunotherapeutic agent against ulcerative colitis” Plant-Based Vaccines, Antibodies & Biologics. June 8 – 10, 2015, Lausanne, Switzerland. 2. Royal J, Oh Y, Galandiuk S, Matoba N. “Epicertin, A Cholera Toxin B Subunit variant, Enhances Intestinal Would Healing in a Mouse Acute Colitis Model and Human Ulcerative Colitis Colon Explants via an Unfolded Protein Response” Digestive Disease Week 2018, June 2 – 5, 2018, Washington, DC. Oral Presentations: Local/Regional Meetings 3. Royal J, Baldauf K, Matoba N. “Plant-Made Cholera Toxin B Subunit: A Candidate Oral Immunotherapeutic Agent Enhances Colonic Mucosal Wound Healing” Center for Predictive Medicine Retreat, November 2016, Henryville, IN. Poster Presentations: National/International Meetings 1. Royal J, Baldauf K, Yaddanapudi K, Dryden GW, Matoba N. “Oral Administration of a Cholera Vaccine Antigen Facilitates Colonic Mucosal Healing in a Murine Model of Colitis” Digestive Disease Week 2017, Chicago, IL, May 6 – 9, 2017. 2. Royal J, Youngjun Oh, Galandiuk S, Matoba N. “Epicertin Enhances Intestinal Wound Healing In A Mouse Colitis Model And Human Ulcerative Colitis Colon Explants” Crohn’s and Colitis Congress, 2018, Las Vegas, NV Poster Presentations: Local/Regional Meetings 1. Royal J, Nelson B, Baldauf K, Kouokam C, Matoba N. “Plant-Made Cholera Toxin B Subunit, an Orally Active Anti-inflammatory Protein, in an Acute Colitis Mouse Model: Investigation of Effective Dose and Time of Administration” Research Louisville 2014, Louisville, KY 2. Royal J, Husk A, Hamorsky K, Bennet L, Matoba N. “Plant-Made Anti-TNFα Monoclonal Antibody; an Infliximab Biosimilar against Intestinal Inflammation and

A recombinant cholera toxin b subunit variant (CTB-KDEL) exhibits unique colon mucosal healing effects that have therapeutic implications for inflammatory bowel disease.