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THE BETA2 ADRENERGIC RECEPTOR POL YMORPHISMS AND RISK OF BREAST CANCER AMONG HISPANIC AND NON-HISPANIC WHITE WOMEN FROM THE 4-CORNERS BREAST CANCER STUDYA POPULATION-BASED CASE-CONTROL EXAMINATION A vonne E. Connor July21,2011 Polymorphisms in the adrenergic receptor beta-2 (ADRB2) gene have been studied in relation to risk of Type 2 diabetes and obesity, but few studies have investigated associations with breast cancer. The purpose of this research was to evaluate the primary hypothesis that ADRB2 variants (rs1042713-Arg16Gly and rs1042714Gln27Glu) are associated with breast cancer risk in non-Hispanic white (NHW) and Hispanic (H) women using data from a population-based case-control study conducted in the southwestern United States: 'The 4-Corners Breast Cancer Study'. A total of 1,244 NHW and 606 H cases with incident primary breast cancer were ascertained and 1,330 NHW and 728 H population-based controls were selected. Information on lifestyle and physical activity, diet, demographics, and reproductive background was collected through an in-person questionnaire, and blood samples were taken for genetic analyses from consenting participants. ADRB2 genotypes for rs 1042713 and rs 1042714 were determined using PCR. Each genotype as well as their haplotypes was evaluated in multi variable logistic regression models to estimate the associations with breast cancer

The beta-2 adrenergic receptor polymorphisms and risk of breast cancer among hispanic and non-hispanic white women from the 4-corners breast cancer study : a population-based case-control examination.