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FLUID DYNAMIC ANALYSIS OF FLOW IN ORBITING DISHES AND THE EFFECTS OF FLOW ON SHEAR STRESS AND ENDOTHELIAL CELLULAR RESPONSES Amlan Chakraborty March 28,2011 This work presents a novel comprehensive effort to understand the fluid dynamics within orbiting dishes and the effects of the resulting oscillating fluid flow on shear and endothelial cellular responses within the dishes. It is well documented that hemodynamic parameters, especially wall shear stress (WSS), have been shown to play important roles in altering various endothelial cellular responses, intracellular pathways and gene expreSSIOn, and to have significant impacts on disease progression, such as atherosclerotic plaque development. In practice, wall shear stress (WSS) is oscillatory rather than steady due to the travelling waveform and varies across the surface of the dish at any instant in time. The first part of this effort presents a computational model which provides complete spatial and temporal resolution of oscillatory WSS over the bottom surface of an orbiting Petri dish throughout the orbital cycle. The model was reasonably well validated by the analytical solution and the results were compared to the tangential WSS magnitudes obtained using one-dimensional optical velocimetry at discreet locations on the bottom of an orbiting dish.

Fluid dynamic analysis of flow in orbiting dishes and the effects of flow on shear stress and endothelial cellular responses.