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THE EFFECT OF TISSUE DAMAGE AND INFLAMMATION ON GENE EXPRESSION IN SENSORY NEURONS Sean A Trusty July 15,2011 This study examined the effects of tissue damage and inflammation on the expression in sensory neurons of P2X3, a gene that has a role in nociception and sensing bladder distension, which is regulated by nerve injury. Tissue damage induces expression of ATF3, an indicator of injury, in sensory neurons. Animals were exposed to different types of tissue damage including single and repeated skin incision, bladder incision and a spinal cord injury with bladder inflammation. P2X3 was regulated differentially between conditions of single and repeated skin incision. One condition that involves repeated tissue damage and alteration of bladder function is spinal cord injury. In a small study of SCI and bladder inflammation we found no change in P2X3 expression in sensory neurons. Changes in expression of genes like P2X3 could have implications for bladder dysfunction and altered nociception.

The effect of tissue damage and inflammation on gene expression in sensory neurons.