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GLYCINE RECEPTOR SUBUNITS -«2 AND a3 PARTICIPATE IN DIFFERENT INHIBITORY CIRCUITS THAT ALTER THE RECEPTIVE FIELD ORGANIZATION OF ONAND OFF-CENTER RETINAL GANGLION CELLS Regina D. Nobles June 30, 2010 In the retina, the receptive fields (RFs) of most neurons are comprised of an excitatory center and a suppressive surround. Retinal ganglion cell (RGC) RF center excitatory input arises from bipolar cell (BC) inputs, while their surround arises from lateral inhibitory inputs. Because of the availability of selective antagonists the role of GABAergic inputs has been well defined. In contrast, the role of individual glycine receptor (GlyR) subunit inhibition is less clear because the antagonist, strychnine, blocks all GlyR subunit combinations. To define individual retinal circuits that utilize specific glycinergic subunits, I examined maintained and visually-evoked responses of ONand OFF-center GCs from mice lacking expression of the GlyRa2 (GlraT-) or GlyRa3 (Glra3--) subunits to those of C57Bll6J (WT) RGCs using an in vivo extracellular approach. Previous observations have defined glycine and GABA inputs across BC classes and in a variety of amacrine and RGCs. Using this information and by comparing the responses of WT vs. Glra2-and GlraTRGCs; I conclude that both subunits modulate local RF interactions. Within the On pathway, GlyRa2 and GlyRa3 inputs play similar roles. Their responses predict that they participate in serial inhibitory circuits that

Glycine receptor subunits -a2 and a3 participate in different inhibitory circuits that alter the receptive field organization of on- and off-center retinal ganglion cells.