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The article interprets the results of a randomized, blind, placebo-controlled, confirmatory clinical study of the efficacy of bovhyaluronidase azoxymer (BA) applied to cats with urological diseases, conducted in parallel groups on the basis of “Bars” veterinary clinics in Petersburg and the Department of Obstetrics and Operative Surgery of St. Petersburg State University of Veterinary Medicine from November 2018 to August 2020. To prove the causal relationship between the application of BA and a significant decrease of the number of complications in the postoperative period, we used a three-stage system for analyzing the results. The reliability of our study is confirmed by the following: 1) a sufficient sample number corresponding to that calculated at the planning stage of the clinical study (53 cats: 24 were included in the experimental group and 29 were in the control group) that had indications for surgery on the urethra and / or bladder; 2) a sufficient value of the confirmed effect: when BA was used, the risk of complications was 80.9% lower, and the chance of complications decreased by 12.2 times; 3) correct randomization and blinding, which made it possible to obtain representative samples: block randomization and blinding by territory were carried out; 4) standardization of animal registration and data collection: all animals were examined in accordance with the requirements of GOST R 58090-2018 “Clinical examination of nonproductive animals”; 5) the presence of placebo control. The revealed decrease of the frequency of complications with BA is explained by the action mechanism of the studied medication in the body. The results of clinical studies indicate that application of BA medication in the therapy of companion animals is clinically justified and can be extended beyond the observed population. The obtained results allow us to assert that application of BA significantly reduces the complications associated with the performed surgical intervention or the recurrence of the disease within six months after the first operation.

ESTIMATION OF RELIABILITY OF CLINICAL STUDY RESULT OF BOVHYALURONIDASE AZOXYMER MEDICATION APPLIED TO CATS WITH UROLOGICAL DISEASES