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It is proved that in hepatopathies of any etiology, there is a decrease in the activity of the antioxidant potential of the body, which leads to a disorder of redox homeostasis of hepatocytes, and can be considered as an independent syndrome. In dogs with comorbidity of babesiosis and dirofilariasis, redox homeostasis disorder was accompanied by the development of hyperproteinemia (total protein -77,82±1,15 g/l) and hypoglycemia (glucose- 2,90±0,25 mmol/l), disorder of the catalytic activity of serum enzymes (AAT - 108,90±1,03 unit/l;  AAT - 74,63±2,20 unit/l; alkaline phosphatase - 105,75±6,10 unit/l; amylase - 1815,6062,20 unit/l; cholinesterase - 221,302,30 mmol/l), a decrease in antioxidant protection (vitamin  А – 0,01±0,001 mcM/ml), in addition, the involvement of the hepatorenal system in the pathological process of sick animals was registered (creatinine - 127,90±1,42 mmol/l;  urea - 14,60±0,38 mmol/l). After pharmacological correction was revealed normalization of indicators of protein (total protein - 62,55±0,80 g/l), carbohydrate (glucose - 5,10±0,30 mmol/l) and lipid (cholesterol - 5,30±1,65 mmol/l) metabolism, optimization of nitrogen metabolism (creatinine - 84,56±1,20 mmol/l;  urea - 5,09±1,62 mmol/l), indicators of the blood enzyme system (AAT - 53,58±1,31 unit/l;  AAt - 30,29±1,83 unt/l; alkaline phosphatase - 83,9±1,01 unit/l; amylase - 1489,4659,43 unit/l; cholinesterase - 345,961,50 mmol/l) and the body's antioxidant potential (vitamin А – 0,03±0,001 mcM/ml) in dogs of the experimental group, which was due to the pathogenetically adequate use of L-glutathione and heptral in the scheme of complex pharmacocorrection of oxidative stress in comorbidity of babesiosis and dirofilariasis.

CORRECTION OF REDOX HOMEOSTASIS OF HEPATOCYTES IN COMORBIDITY OF BABESIOSIS AND DIROFILARIOSIS IN DOGS