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Hongmin Wang*, Yaru Feng, Huan Li Zhengzhou Sias University, Zhengzhou 451150, Henan, China. E-mail: hongmin_wang699@126.com Fund Project: Zhengzhou Sias College’s 2019 Education Reform Fund Project: Nursing-Mini-CEX Combined with Online and Offline Hybrid Teaching Model Application Research in Basic Nursing Training Teaching. Project No. 2019JGYB72 Abstract: Objective: To explore the application effects and countermeasures of Nursing-Mini-CEX combined with the online and offline hybrid teaching model in basic nursing training. Methods: Taking 150 students from the 2017 grade as an example, the effects of traditional teaching mode and NursingMini-CEX combined with mixed model teaching were compared. Results: The performance of the intervention group combining Nursing-Mini-CEX evaluation and mixed teaching was significantly higher than that of the control group, and the difference was statistically significant (P<0.05). Conclusion: The combination of Nursing-Mini-CEX measurement tools and mixed teaching is feasible and effective in basic nursing training.