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In recent years, there has been interest in research relating to hyperthermia skin cancer treatment. However, obtaining accurate temperature distributions in living tissue without using an intruding sensor is a challenge. The purpose of this study is to develop a mathematical model that can accurately determine the temperature distribution in the tumor region and surrounding normal tissue. Our model is based on a modified Pennes’ equation for the bioheat transfer in a 3-D triple-layered skin structure embedded with a vascular countercurrent network and a tumor appearing in the subcutaneous region. The vascular network is designed based on the constructal theory of multi-scale tree-shaped heat exchangers. The tumor is injected with golden nanoparticles in order to heat up the tumor quickly. The proposed model will be solved numerically using an unconditionally stable finite-difference scheme. We expect our method can be a useful tool to provide the optimal laser irradiation in order to eradicate the tumor through hyperthermia treatment while keeping the damage to the surrounding healthy tissue to a minimum.

Numerical hyperthermia simulation for A 3-D triple-layered skin structure with embedded vascular countercurrent network and nanoparticles