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espanolIntroduccion: Analogos del alcaloide girgensohnina, disenados y sintetizados para inhibir a la enzima acetilcolinesterasa, han presentado efecto insecticida sobre insectos vectores de enfermedades. Objetivo: Determinar la actividad insecticida de 12 analogos sinteticos de gingersohnina sobre ninfas del primer estadio de Triatoma dimidiata. Materiales y Metodos: Se tomo como referencia el protocolo de la OMS 2005. Ninfas del primer estadio de T. dimidiata fueron expuestas a los analogos por aplicacion topica y exposicion a superficies para determinar las dosis letales (DL50 y DL95) y verificar alteracion en la locomocion mediante el software Videomex V. Resultados: El analogo 6 presento la mayor actividad insecticida a las 72h con una mortalidad del 20,8% ± 3,57 para el tratamiento de topicacion 25% ± 0,00 para las superficies no porosas. Las dosis letales de la molecula 6 fueron: DL50 1036,8 ± 0,38 ng/insecto y DL95 3991,4 ± 0,50 ng/insecto respectivamente. Con respecto a la locomocion, el analogo indujo un comportamiento similar al insecticida comercial deltametrina. EnglishIntroduction: Analogs of the girgensohnine alkaloid, designed and synthesized to inhibit acetylcholinesterase enzyme, have presented an insecticidal effect on vectors insects of diseases. Objective: To determine the insecticidal activity of 12 synthetic analogs of gingersohnine in first stage nymphs of Triatoma dimidiata. Materials and methods: WHO protocol 2005, using exploratory doses, was used to determine the best molecule according to its mortality. First stage nymphs of T. dimidiata were exposed to different doses of the analogs by topical application and surface exposure. Lethal doses (LD50 and DL95) and alterations in locomotion using Videomex V software were determined. Results: Analog 6 presented the highest insecticidal activity at 72 h with a mortality of 20.8% ± 3.57 for topical treatment and 25%±0,0 for non-porous surfaces evaluation. Analog 6 lethal doses were LD50 1036.8 ± 0.38 ng/insecto and DL95 3991.4 ± 0.508 ng/insecto, respectively. With regard to locomotion, analogue 6 induced a similar behavior to that observed for commercial insecticide deltametrin.

revista de la universidad industrial de santander/salud uis

Toxicidad y afectación en la locomoción de Triatoma dimidiata (Latreille 1811) (Hemiptera: Reduviidae: Triatominae) tratados con análogos de girgensohnina