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In the zone formed by Urabá Antioqueño-Cuencas altas de los ríos Sinú and San Jorge-Bajo Cauca Antioqueño (hereinafter, the Region), 60% of the Colombian cases of malaria are described. The Region is not specifically addressed in official reports and even malaria researchers do not refer to it precisely. The objective of this review is to argumentatively describe what is the Region. This is a theoretical descriptive study, which proposes that 1. Universidad de Antioquia. Medellín, Colombia Correspondencia: Jaime Carmona Fonseca. Dirección: Carrera 51 D #62-29, oficina 336. Medellín, Colombia. Teléfono: +57 219 60 25. Fax: 219 60 51. Correspondencia: jaimecarmonaf@hotmail.com Recibido: 27/06/2017 Aprobado: 30/06/2017 Publicado online: 10/09/2017

La Región “Urabá Antioqueño-Cuencas altas de los ríos Sinú y San Jorge-Bajo Cauca Antioqueño”: “guarida” del paludismo colombiano