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espanolObjetivos: Determinar y comparar la sensibilidad hepatica a la insulina en residentes permanentes a nivel del mar (Lima, 150 msnm, Patm [presion atmosferica] = 760 mm Hg) y en altura (Huancayo, 3 250 msnm, Patm = 520 mm Hg). Metodos: Se utilizo el metodo CLAMPEH, considerado el de mayor exactitud para determinar la sensibilidad a la insulina, y que consiste en la infusion por via venosa, instalando dos cateteres antebraquiales de una cantidad fija de insulina y una cantidad variable de graduada con una bomba de infusion volumetrica. La sensibilidad hepatica a la insulina se represento mediante el valor (M), que indica la relacion entre la cantidad de glucosa infundida con una hiperinsulemia para mantener valores de glicemia de 100 mg/dL, siendo el valor estandar para esta relacion 1 (en el grupo de edad de menos de 25 anos y con 90-110 % del peso ideal). La muestra estuvo compuesta por 16 residentes permanentes por mas de 5 anos en cada ciudad, con un indice de masa corporal (IMC) entre 20 y 25 kg/m2 y una edad entre 20 y 25 anos. Resultados: Encontramos que la sensibilidad hepatica a la insulina es significativamente mayor (P EnglishObjectives: To determine and to compare the hepatic sensitivity to the insulin in permanent residents from sea level (Lima, 150 m.s.l, Patm [Atmospheric pressure] = 760 mm Hg) and from high-altitude (Huancayo, 3250 m.s.l, Patm = 520 mm Hg). Methods: It was used the CLAMPEH method. It’s considered the one with more accurately to determine the sensitivity to the insulin, which involves the infusion via venous, and to install two antebrachial catheters with an insulin fixed amount and a variable amount with a volumetric infusion pump. The hepatic sensitivity to the insulin was represented by the value (M) which indicates the relationship between the glucose amount infused with a hyperinsulinemia, to maintain glycemia values of 100 mg/dL, being the standard value 1 for this relationship (in the age group under 25 and 90-110 % of ideal weight). The sample was composed by 16 permanent residents for more than 5 years in each city, with a body mass index (BMI) between 20 and 25 kg/m2 and an age between 20 and 25. Results: We found that the hepatic sensitivity to the insulin was significantly higher (P

Sensibilidad hepática a la insulina en residentes en zonas de altura y de nivel del mar utilizando el método CLAMPEH