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Hybrid compounds formed by biomolecules and nanometric structures are attracting interest for the development of applications in the fields of biosensors and drug delivery. In this study we prepared a grapheme-folic acid conjugate which we characterized by Raman spectroscopy and the density functional theory (DFT) computational method. The non-covalent conjugate was performed through a simple and fast one-pot method. The analysis of ratio intensity of D and G bands in the Raman spectroscopy evidenced graphene functionalization. The DFT method showed that the bond between graphene and folic acid occurs by non-covalent π-π and hydrogen bond interactions. Graphene and folic acid conjugates will allow the design of biosensors for the detection of cancer cells overexpressing folate receptors using analytic devices for a faster, more effective and timely diagnosis of cancer. © 2018. Acad. Colomb. Cienc. Ex. Fis. Nat

Caracterización del conjugado no covalente de grafeno y ácido fólico mediante espectroscopia Raman y métodos computacionales