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The platelets play a vital role in the pathological changes in diabetes leading to micro-vascular complications. Platelet indices being indicators of platelet activity, may be useful predictive markers of these complications. The aim of this study was to evaluate the platelet indices in diabetic patients and correlate them with micro-vascular complications of the disease. We included 60 patients of Type 2 diabetes and 60 non-diabetics in this case-control study. Detailed clinical history including duration of diabetes and presence of micro-vascular complications was noted. Platelet indices - (Platelet count-PLT, Mean platelet volume-MPV, Platelet distribution width-PDW and Plateletcrit-PCT) were obtained using automated cell counter. Fasting blood glucose and HbA1c were also obtained. Diabetics were further categorized into patients with complications and without complications. Statistical analysis was performed by EPI INFO software version 7, Student's t-test and ANOVA test. The study showed that MPV was significantly higher in Diabetics than non-diabetic controls (p<0.05). HbA1c (p<0.05) and duration of diabetes (p<0.05) were statistically significantly higher in diabetics with microvascular complications as compared to diabetics without microvascular complications. MPV showed statistically significant difference between diabetics with and without complications and nondiabetics (P < 0.05). PDW and MPV were positively correlated with duration of diabetes. Duration of diabetes was significantly higher in diabetics with retinopathy (<0.05) and neuropathy (p<0.05). Diabetics have higher MPV. MPV and PDW are predictive biomarkers of diabetic micro-vascular complications. Keywords: Diabetes, Platelet indices, Platelet count, Mean platelet volume, Platelet distribution width, Plateletcrit.

Platelet indices in type 2 diabetes mellitus and their association with microvascular complications