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Gall bladder lesions include the varied spectrum of lesions encompassing inflammatory,benign, premalignant and malignant conditions. Progression from benign to malignant change is acomplex process. The pathological importance of chronic inflammation leading to neoplasia has comeinto prominence in recent years. Multiple mechanisms are involved in the carcinogenesis and the mostcommonly disrupted gene is the p53 gene.Materials and Methods: In our prospective study, of three consecutive years duration a total of 262specimens which included inflammatory, premalignant, and malignant lesions of the gall bladder werereceived. Immunohistochemical analysis with a p53 antibody was done on selected 60 specimens accordingto our inclusion criteria.Results: Of the received specimens majority (84.7%) were inflammatory lesions followed by precursorlesions (10.7%) and malignant lesions (4.5%). Chronic cholecystitis with cholelithiasis is the predominantlesion accounting for 33% of the cases. P53 expression was observed in 50% of malignancies and was notseen in any of the premalignant conditions. 11.8% of inflammatory lesions with thickened wall showed p53expression.Conclusion: The most common histopathological diagnosis was chronic cholecystitis. Chronicinflammation is a major risk factor for malignancy. Careful pathological examination of gallbladderspecimens should be done as the neoplastic process may present silently as cholecystitis. P53 expressionin chronic inflammatory conditions indicates an important role of inflammation in chronic cholecystitiscarcinomasequence. Early detection of p53 mutation by Immunohistochemical analysis, and regular followup aid in optimal patient management.Keywords: Gall bladder, Cholecystitis, p53.

Histomorphological spectrum of gall bladder lesions, relation to p53 expression