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Aims and objectives of our study was to detect the most common tobacco related lesionswhich occurs in oral cavity with respect to age, sex, duration of tobacco use, distribution of premalignantand malignant lesions and to correlate the scrape cytology findings with histopathology in Mumbai regionof Maharashtra.Materials and Methods: Total of 85 cases having tobacco associated intra oral lesions were analyzedretrospectively 5 years. Cases were studied in detail and included complete clinical history andexamination, addictions, scrape cytology and histopathological findings.Result: In our study, males were commonly involved (62 cases, M:F=2.7:1), commonest addiction wassmoking tobacco (33%) and tobacco with lime (31%) and producing lesions at right and left buccal mucosa(36.2%) and lateral borders of tongue (20.5%) most frequently, in a age group of 41 to 50 years (31.7%)followed by 51 to 60 years (28.2%). In a 42 premalignant lesions, oral submucosal fibrosis were seen in40.47% and leukoplakia in 38.09% cases. Remaining 60 malignant cases, well differentiated squamouscell carcinoma were seen in 46.66% and moderately differentiated squamous cell carcinoma in 43.33 %cases. The sensitivity and specificity of scrape cytology in detecting oral squamous cell carcinoma were88.33% and 100% respectively. Positive predictive value was 100%, negative predictive value was 85.7%with diagnostic accuracy of 93.14%.Conclusion: Strong association of prolong use of tobacco products and smoking to have premalignant andmalignant intraoral lesions at the site of placement of tobacco was established. Intra oral scrape cytologycan be a main screening tool for early diagnosis along with histopathology correlation.Keywords: Tobacco, intra oral lesions, Scrape cytology, Oral submucosal fibrosis, Leukoplakia, Squamous cell carcinoma.

Tobacco related oral cavity lesions, scrape cytology with histopathological correlation: A 5 year study at tertiary level hospital in Mumbai