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Bcl 2 is one of the unique proto-oncogene, localized to mitochondria & interfering withapoptosis independent of promoting cell division. Bcl-2 is overexpressed mostly in SCLC and in a minorityof the NSCLC. Cyclin D1 is an important cell cycle regulatory protein which controls the cell cycletransition from G1 to S phase.Materials and Methods: Here, we studied immunohistochemical expression of Bcl 2 & Cyclin D1 in 40lung cancer patients to evaluate the immunohistochemical expression of Bcl 2 & Cyclin D1 in primary lungcancer, its expression with histological subtypes of lung cancer & to correlate the expression of Bcl 2 &Cyclin D1 with the clinical stage of disease.Results: The immunohistochemical expression of Bcl 2 & Cyclin D1 was studied in 40 cases of lungcancer and was also correlated with the histological subtypes. Out of 40 cases of lung carcinoma, 21 cases(52.5%) were positive and 16 cases (40%) were negative for Bcl 2. Among histological subtypes, Bcl 2was significantly higher in patients with small cell carcinoma, (80%) followed by squamous cell carcinoma,(78.57%). Out of 40 cases of lung carcinoma, 16 cases (40%) were positive and 21 cases (52.5%) werenegative for Cyclin D1. Among histological subtypes, expression of Cyclin D1 was significantly higherin patients with adenocarcinoma, (52.38%) as compared to Squamous cell carcinoma (35.71%). Theimmunohistochemical expression of Bcl 2 and Cyclin D1 was correlated with the clinical staging of lungcancer. We observed higher Bcl 2 expression in stage 3 disease (81.82%) followed by stage 4 disease(55%). Higher Cyclin D1 expression was seen in patients with stage 4 disease (80.00%). None of the stage2 and stage 3 patients showed any expression with cyclin D1.Conclusions: In our study, higher Bcl 2 expression was associated with small cell carcinoma of lungand among non small cell carcinoma its expression was higher in squamous cell carcinoma. Cyclin D1expression was observed mostl

Immunohistochemical expression of Bcl 2 &amp; Cyclin D1 in lung cancer and its correlation with histological type &amp; clinical staging

Immunohistochemical expression of Bcl 2 & Cyclin D1 in lung cancer and its correlation with histological type & clinical staging