English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective: The revised 4th edition of the WHO classification of tumours of the central nervous systemcategorizes meningiomas into three grades based on their histomorphology. However, the biologicalbehaviour and recurrence rates for these tumours cannot be predicted using morphology alone. The aim ofthe study was to study the demography of Meningiomas and to correlate the grade with the Ki-67 LabellingIndex (LI) and compare them to tumour recurrence.Materials and Methods: The study included 38 cases of Meningioma of various subtypes. Hematoxylinand Eosin slides were reviewed; appropriate blocks were sectioned and stained with Immunohistochemicalmarker, Ki-67. Slides were studied and Ki-67 labelling index was calculated.Results: The tumour was more common in the female population and in the 5th and 6th decades of life.The average Ki67 labelling index showed insignificant variation among tumours within the same grade (p=0.15) but demonstrated considerable disparity with increasing grades (p of recurrence of a previous Papillary Meningioma, with a Ki-67 index of 25.32.Conclusion: Ki67 labelling index in meningiomas increases in proportion to increasing grade and is agood indicator of tumour recurrence. Some histologically benign tumours have been known to recur aftercomplete excision. Hence, we suggest that immunohistochemistry for Ki-67 LI should be done for all casesof meningioma, irrespective of the type.Keywords: Meningioma, Ki 67, Tumor, Grade, CNS.

A histomorphological study of meningiomas with relation to Ki-67 proliferative index and review of literature