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Introduction: Cancer is a global health burden affecting every region and socioeconomic levels. Gastric cancer is the fifth most common cancer in the world. Despite an overall declining incidence, gastric adenocarcinoma remains the second most common cause of death worldwide due to malignant disease. Materials and Methods: A cross sectional study was done in the Department of Pathology, in a Tertiary care centre in central part of Kerala during a period of 18 months (January 2014 July 2015). Gross examination and morphological assessment of 60 gastrectomy specimens received in the department were done. Study was approved by institutional ethical committee. Results: 68.3 percentage of cases were located in the pyloric region. 65 percentage cases had extension into serosa. 46.7 percentage cases were intestinal type.33.3 percentage diffuse type, 16.7pércentage mixed type and 3.3 percentage mucinous type were seen. 51.6 percentage cases were in pTNM stage 2. Conclusion: Most of the gastric carcinomas were intestinal type. Cases showed a predominance of pathological stage 2 in this study. Introduction Gastric cancer is the fifth most common cancer in the world with the highest incidence in Asia, Latin America and Caribbean and the lowest incidence in Africa and Northern America. Cancers of the antropyloric region are more common in the high-risk regions whereas in the low-risk regions, tumours of the cardia predominate. Men are affected more frequently than women, with a male to female ratio of 2:1. Low socioeconomic status, high intake of salt and dried or pickled foods, smoking and alcohol consumption are some of the environmental factors implicated in gastric cancer whereas vitamin C in fresh fruits and vegetables, carotenoids and green tea are protective. Clinicopathologically, gastric carcinoma can be classified into two broad categories. First one is the early gastric cancers or superficially invasive lesions which are limited to the mucosa or the mucosa and submucosa, regardless of nodal status. The second one is the advanced adenocarcinomas extending at least to the muscularis propria. The prognosis of early gastric carcinoma is excellent, with a 5 year survival rate as high as 90%. Another most commonly used categorisation of gastric adenocarcinoma is the histologic classification of Lauren which subdivides gastric adenocarcinoma into two main types: intestinal and diffuse. Histologically, gastric carcinoma demonstrates marked heterogeneity in architecture and pattern of growth. These are histologically classified by WHO. Tumor location and histologic type should prompt specific concerns. Diffuse carcinoma of the antropyloric region have a high frequency of serosal and lymphovascular invasion and lymph-node metastases. Staging was done according to pTNM staging for gastric carcinoma. Materials and Methods It was a cross sectional study to histomorphologically study all the gastrectomy specimens received in Department of Pathology, which are histologically diagnosed as gastric and gastroesophageal junction carcinomas. 60 cases were collected and examined. Inclusion Criteria Resected specimens received in the Department of Pathology, during the study period, which were diagnosed histologically as gastric and gastroesophageal carcinoma. Exclusion Criteria Small biopsy specimens were excluded. Methodology Gross examination of gastric and gastroesophageal carcinomas was done and tumour site, tumour size, appearance of the cut surface, depth of tumour invasion , appearance of the adjacent mucosa and lymph nodes sampled were documented. Tissue sampling was done. Article Info Received: 5th February, 2019 Accepted: 12th March, 2019 Published Online: 9th August, 2019

Gastric and gastroesophageal junction carcinomas and its morphological features, tertiary care centre study