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The spectrum of conjunctival lesions range from degenerative and inflammatory lesions to benign or malignant neoplasms. Hence it is important for these lesions to be recognised and treated appropriately to prevent complications. Objectives: To assess the histomorphological features of various conjunctival lesions, to classify them, to see the age and sex distribution and the frequency of various conjunctival lesions received in Department of Pathology. Materials and Methods: The clinicopathologic details of excised conjunctival lesions were reviewed retrospectively in our tertiary care centre over a period of 10 years. Result: The conjunctival lesions are more common in males and right eye. Pterygium is the commonest benign lesion and Squamous cell carcinoma is the most common malignant conjunctival tumour. Benign conjunctival lesions were more common than the malignant ones in our study. Conclusion: The most frequent conjunctival lesion was Pterygium in our Tertiary Care Centre. The most common malignant conjunctival tumour was Squamous Cell Carcinoma. Introduction The conjunctiva is a specialised thin flexible mucous membrane that lines the sclera and inside of both upper and lower eyelids. The palpebral conjunctiva lines the undersurface of eyelids, the forniceal conjunctiva forms conjunctival cul-de-sac and the bulbar conjunctiva covers the anterior surface of the globe. Microscopically, conjunctiva is composed of non-keratinizing squamous epithelium along with mucin-secreting goblet cells. The mucous secretion from the goblet cells contribute to the stability of the tear film. The conjunctiva protects the cornea and interior of the eyeball from external environment while facilitating movements of the globe and eyelids. The conjunctival tumours can be congenital or acquired and show a broad spectrum ranging from non-neoplastic benign tumours to aggressive malignant tumours such as Squamous cell carcinoma, Malignant Melanoma or Kaposi Sarcoma. These aggressive lesions often threat the visual function and life of the patient. In addition to histopathological evaluation of conjunctival tumours, a meticulous slit lamp examination of cornea is often needed to assess the degree of invasion. Ocular surface tumours include neoplasm originating from squamous epithelium, melanocytes and the resident lymphocytic cells in the conjunctival stroma. Epithelial dysplasias, carcinoma-in-situ and squamous cell carcinomas involving the conjunctiva and cornea are grouped into Ocular Surface Squamous Neoplasia (OSSN). The incidence of OSSN is about 0.2 to 12 cases per 1,000,000 population per year and shows ethnic and geographic variations. Conjunctival epithelial lesions are known to be associated with exposure to sunlight, old age, male sex, fair skin, Human Papilloma Virus subtypes 6, 1, 16, 18 and Human Immunodeciency Virus infection. As stated by Newton et al, with every 10 decline in latitude, there is an increase in the incidence of ocular Squamous Cell Carcinoma by 49%. Most studies done on ocular lesions show that conjunctival lesions contribute to majority proportion, after eyelid lesions. Lesions of conjunctiva are not uncommon in histopathology laboratories. As a group, the conjunctival lesions are commonly seen in the clinical practice of an Opthalmologist. As conjunctiva is readily visible, the related lesions can be recognised and diagnosed at a relatively early stage to preserve visual function and to prevent local and systemic spread. There is a paucity of large published series documenting conjunctival lesions. The literature on epidemiology and histopathology of excised conjunctival lesions is relatively sparse in India. We have conducted the [resent study with an aim to characterize the epidemiologic and histopathologic profile of all benign and malignant conjunctival lesions from a Tertiary Care Centre in Karnataka, South India. Article Info Received: 2nd November, 2018 Accepted: 23rd February, 2019 Published Online: 9th August, 2019

A 10-year retrospective study of histopathological spectrum of conjunctival lesions in a tertiary care centre from south India