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Transfusion transmissible infections (TTI) are a major threat for the recipients of blood and blood products. Voluntary blood donations (VBD) are considered safe to Replacement blood donations (RBD). Our main of the study is to find out the seroprevalence of TTIs in our area and also to find out whether there is a significant difference in seroprevalence of TTIs between VBD and RBD. Materials and Methods: It is a retrospective, cross sectional study carried out in the regional blood bank of a tertiary care centre. Records of total 33341 blood donations carried out in a period of 6 years (January 2012 to December 2017) were studied for calculating the seroprevalence of HIV, HBsAg, HCV and Syphilis. Comparison of seroprevalence between VBD and RBD was done. Results: Predominant donor population was male (91.86%). 91.63% donations were VBD and 8.37% donations were RBD. Most common type of TTI was HBsAg (85.9%) followed by HIV (6.72%), HCV (4.98%) and Syphilis (2.38%) respectively. The difference in seroprevalence of TTIs between VBD and RBD was statistically significant (p value <0.05). Conclusion: There is seen statistically significant difference in seroprevalence of TTIs between VBD and RBD suggesting RBD are at more risk for transmitting TTIs than VBD. Hence we recommend regular, non-remunerated, voluntary blood donations for assuring better safety and quality of blood and blood products.

Comparison of seroprevalence of transfusion transmissible infections between voluntary and replacement donors at a tertiary care center