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Background: The incidence of surgical site infections is higher in India compared to the rest of the world.In orthopedic surgeries, the risk is even higher. Surgical site infections following orthopedics are associatedwith an additional length of stay resulting in additional costs thus causing a significant economic burden onpatients and society.We aimed to determine the additional costs and length of stay and evaluate the efficacyof triclosan-coated sutures in reducing surgical site infections rate.Materials and Methods: A systematic literature search of available evidence for both epidemiologicand economic data pertaining to the incidence of surgical site infections and efficacy of triclosan-coatedsutures, from 1998-2018 and 2000-2018 respectively, were gathered. We compared 100 surgeries fromprivate and public hospitals from orthopedics and calculated cost-effectiveness of triclosan-coated suturesin comparison to conventional non-coated sutures using a decision-tree cost model.Results: Two studies were analysed for analysis of surgical site infections’ incidence and for the efficacy oftriclosan-coated sutures vs non-coated sutures, 3 studies were included.We performed a one-way sensitivityanalysis to calculate the impact of % efficacy and surgical site infections’ incidences %, cost of noncoatedand triclosan-coated sutures on cost savings depicted by Tornado charts. Sensitivity analysis on thecomparison of triclosan-coated sutures with non-coated sutures, a base cost saving of orthopedic surgeriesfor a private hospital was is INR -5573 and public hospital INR -1410.Conclusion: The use of triclosan-coated sutures reduced surgical site infections incidence and cost savingsfor orthopedic surgeries in both public and private sectors in India.Keywords: Orthopedic, Non-coated suture, Surgical site infection, Triclosan-coated suture.

An economic model to assess the value of triclosan-coated sutures in reducing the risk of surgical site infection in orthopedic surgeries in India