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Proteinuria is a major component of preeclampsia. Urine protein measurement after 24-hoururine collection is the traditional standard method for the detection of proteinuria. It is time-consuming.As an alternative, spot sampling for a urine protein to creatinine ratio (PCR) ratio has been investigated.Aim & Objectives: To determine the accuracy of the spot protein- creatinine ratio in comparison with 24hours urine collection for detection of proteinuria in pre- eclamptic patients.Materials and Methods: A hospital based prospective study was conducted with 120 patients to assessthe quantification of proteinuria in preeclamptic patient and comparing the two methods i.e. 24-hr urineprotein levels and random protein creatinine ratio conducted at tertiary care centre.Results: There was a good positive statistical correlation between 24-hour total urinary protein level andspot protein: creatinine ratio with a correlation coefficient (r) of 0.769.Conclusion: Random and spot urineprotein creatinine ratio can predict with high accuracy the amount of 24- hour urine protein excretion. Theurine PCR is reliable, relatively faster and accurate for proteinuria and can correlate well with 24-hoururinary protein excretion which is gold standard.Keywords: Preeclampsia,Proteinuria, 24-hour urine collection, Spot urine PCR (protein to creatinine ratio)

indian journal of obstetrics and gynecology research

A comparative study of the accuracy of the spot Protein-Creatinine Ratio (PCR) vs 24 hours urine collection for detection of proteinuria in pre- eclamptic patients and its effect maternal and fetal outcomes