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Brain`s neuro protection is clearly the new frontier in movement disorder research and therapy. The long-term clinical studies have so far failed to prove that high-frequency stimulation has been able to slow down the evolution of the disease. So called e a r l y s t i m clinical p r o t o c o l s have only proven that it was safe to induce or stimuli sub thalamic nucleus S T N much earlier than it was so far accepted. At the experimental level, M P T P - treated monkeys, high-frequency stimuli of the S T N could protect neurons in the sub stantia nigra. To test this scientific rationale/hypothesis in humans, one would need to perform S T N induced stimuli at the very beginning of the disease, which is not easily ethically sustainable given the surgical risk, even if low, in patients who are still minimally impaired by the disease. There have been so many advancements in computing capabilities; big data management; miniaturization of electronics, devices and batteries; and new sources of energy compatible with implantation of biological devices and fuel cells. More recently, there has been an explosion of biological imaging at the nano level as well as whole-brain imaging. It is impossible to generate a reasonable picture of future technological development without being sure to be wrong. The consequence of that is that when building projects and setting new protocols as well as imagining new tools and devices, we should be confident that what has not yet been developed will eventually be created. In this article we the author explained the present past and future Parkinson`s disease prediction.

Analysis of Parkinson‘s disease movement disorder by M E R with S T N – Deep Brain Stimulations