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Exposure to cadmium and consumption of herbal alcoholic beverages (HAB) is rising in Nigeria, therebyleading to the increase in the risk of neurodegenerative disorders. Preventing the damages caused bythese exposures will be a valuable approach in managing neurodegenerative disorders associated with thisexposure. In folkloric medicine moringa oleifera is used to manage many disease conditions especiallyneurodegenerative diseases. This study is therefore aimed at investigating the neuroprotective properties ofMoringa Oleifera in cadmium and (HAB) induced frontal cortex damage in Wistar Rats.Eighty Wistar Rats 73g-151g were used for the study. The rats were randomly divided into eight groupsA, B1, B2, C1, C2, D, E, and F of 5 rats each. group A served as control which received 2.5mg/kgbwphosphate buffer intra-peritoneally, while group F served as Moringa-treated control and received oraladministration of 2.0 mg/kgbw Moringa oleifera. Groups B1, B2, D and E were injected intra-peritoneallywith 3.5mg/kgbw CdSO4.8H2 Osingle dose. Group C1, C2 and D received oral administration of 0.5 mlHAB and group B2, C2and E were administered orally with 2.0mg/kgbw Moringaoleifera. The interventionlasted for four weeks and the tissues were processed histologically.Activation of astrocytes were evident in group B1, C1, C2 and D which were exposed to cadmium andHAB while those of groups B2, C2 and E showed ameliorative effect that were evident in reduction in thenumber of swelling and pyknotic neurons and reduction of activated astrocytesMoringa oleifera has neuroprotective properties in the frontal cortex by reducing the numbers of activatedastrocytes.Keywords: Cadmium, Frontal cortex, Moringa oleifera Beverage, Astrocytes

Neuroprotective properties of Moringa Oleifera in cadmium and herbal alcoholic beverage induced frontal cortex damage in Wistar Rats