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Background: Migraine and mood disorders are common clinical problems with significant disability. The aim of this study was to identify the prevalence of undiagnosed mania in migraneurs and to characterize their clinical features. Materials and Methods: Patients attending the neurology outpatient department of a tertiary level teaching hospital during a period 01-01-2017 to 31-07-2017 were enrolled in this observational study. Patients were diagnosed to have migraine as per International Classification of Headache Disorder 3 beta criteria. The Young’s Scale was applied to subjects identified as having mania. The clinico-epidemiological features and the correlation between the occurrence and severity of manic symptoms and migraine were assessed. Results: Majority were females, 162(76.8%) whereas males constituted only 49(23.2%). The mean age was 33.89(±8).Only 34(16.1%) patients-29 females and 5 male patients had mood changes (p = 0.14).24 patients with nausea and vomiting had associated mood changes with no statistically significant difference among the groups (p=0.08).Only 12 subjects (5.7%) had aura during headache.5.2% of patients had mania with mean Youngs Mania Rating Scale(YMRS) of 32.36 (±8.3) in the sample. Five patients(45.45%) out of the 11 subjects who had mania in our study exhibited manic symptoms also during headache episodes. Conclusions: Undiagnosed mania occurred at a rate of 5% in migraine patients in our study population. No definite clinical features like age or migraine features like aura were found to significantly correlate with the presence /severity of mania.45.45% patients had simultaneous mania symptoms and migraine, a phenomenon we term as” migrainous joie de vivre”.  Keywords: Migraine, Mania, Migrainous joie de vivre.

Undiagnosed mania in migraineurs and the phenomenon of migrainous joie de vivre