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Background & Objectives: Methicillin resistant staphylococcus aureus (MRSA) has always been aworldwide problem, although its prevalence varies considerably among countries. The epidemiology ofMRSA has changed over the years and infections are no longer confined to the hospital setting, but appear inhealthy community dwelling individuals with no risk factors. From skin and soft tissue infection, commonorganism isolated is Community associated MRSA (CA-MRSA). Hence the study was done to know theprevalence of MRSA among community associated skin and soft tissue infections in Basaveshwar teachingand general hospital, attached to M.R. Medical College, Gulbarga.Materials and Methods: Standard techniques were used to isolate Staphylococcus aureus from clinicalspecimens. Cefoxitin disc diffusion was used to find MRSA. Antibiogram of MRSA was detected by KirbyBauer disc diffusion method. Inducible Clindamycin resistance was done by Double Disc Diffusion method(D test).Results: From over 200 cases of CA-MRSA, total of (75.5%) staphylococcus aureus was detected. Outof them, CA-MRSA was 27 (17.9%). These showed high sensitivity to Vancomycin (100%), Linezolid(96.2%),Cindamycin (92.59%), moderately susceptible to TMP-SMX(85.1%), Rifampicin (88.1%),Tetracycline(81.4%),Gentamicin (70.3%), ciprofloxacin(62.9%) and a low susceptibility to Erythromycin(48.14%). 14.8% of CA-MRSA strains were D test positive (inducible MLSB positive) and 29.63% were Dtest negative (MS phenotype). 7.4% of CA-MRSA were positive for constitutive MLSB resistance.Conclusion: There is a need for judicious selection of antimicrobial agents, as their indiscriminate use canexert pressure in selecting MRSA and other multi-drug resistant organisms. Further spread of communityacquired infections can be done by effective infection control programs.Keywords: Community associated methicillin resistant staphylococcus aureus(CA-MRSA), Cefoxitin disc diffusion method, Double disk diffusion method

indian journal of microbiology research

Clinico-microbiological study of community acquired MRSA from skin and soft tissue infections and its antibiogram in a tertiary care hospital in Karnataka