English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Acinetobacter spp. is one of the most common opportunistic bacterial pathogen causinghospital acquired infections. Its extensive resistance spectrum has earned it a “red alert” label amonghuman pathogens. The emergence of MBL production among Acinetobacter spp has proved a global threatdue to its broad spectrum of activity and limited treatment options.Aims: To determine the prevalence of MBL among clinical isolates of Acinetobacter spp in a tertiary carehospital and to determine their antibiotic susceptibility pattern.Materials and Methods: 57 clinical isolates of Acinetobacter spp obtained over a period of 1 year wassubjected to antibiotic susceptibility testing by Kirby Bauer disc diffusion method as per CLSI guidelines.The carbapenem resistant strains were screened for MBL production by Imipenem-EDTA Combined disctest and Double disc synergy test. MBL E-test was used for confirmation of MBL production.Results: Of the 57 isolates, carbapenem resistance was recorded in 39 isolates. Screening tests for MBLshowed 24 to be positive by CDT and 16 to be positive by DDST. All 24 of the Acinetobacter sppisolates that tested MBL positive by the screening test showed positive result by E-test. The prevalenceof confirmed MBL by E-test among Acinetobacter spp was found to be 42.2%. The MBL isolates, inaddition to resistance to cephalosporins and carbapenems, showed statistically significant resistance tofluoroquinolones and aminoglycosides. Colistin was found to be 100% sensitive and hence may prove apossible therapeutic option.Keywords: Metallo -beta-lactamase, Acinetobacter, Combined dist test, Double disc synergy test, E-test.

Metallo-beta-lactamase mediated resistance in clinical isolates of Acinetobacter spp