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and Objectives: Expression of inducible clindamycin resistance (iMLSB) byStaphylococcal isolates limits the effective use of clindamycin resulting in treatment failure. The presentstudy was aimed to estimate the prevalence of iMLSB.Materials and Methods: Fifty Staphylococci isolated from various clinical specimens were identified bystandard microbiological methods and were subjected to antibiotic susceptibility testing by Kirby-Bauerdisc diffusion method and D test. Methicillin resistance was detected by cefoxitin disc diffusion method.Results: Staphylococcus aureus constituted 62% and co-agulase negative Staphylococci 38% of totalStaphylococcal isolates. Methicillin resistance was noted in 27(54%) of isolates. Seventeen (34%) isolateswere sensitive to both erythromycin and clindamycin. Among the resistant phenotypes, constitutiveclindamycin resistance (cMLSB), Macrolide Streptogramin B resistance (MS) phenotype and iMLSBwas found in 16 (32%), 10 (20%) and in 7(14%) isolates respectively. Majority of the Staphylococcalisolates showed resistance to penicillin (93.6%) followed by ciprofloxacin (79.6%) and erythromycin(66%). Linezolid resistance was observed in 8% of isolates. None of the isolates were found resistantto vancomycin.Interpretation and Conclusion: Routine testing for iMLSB for all clinical isolates of Staphylococcishould be carried out to prevent failure of clindamycin therapy. Isolation of linezolid resistantStaphylococci is an alarming sign and a matter of concern.Keywords: D test, Inducible clindamycin resistance, Methicillin resistance, Staphylococci.

Antibiogram of staphylococcal isolates with special reference to inducible clindamycin resistance