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Objectives: Aim of this study was to show the association between retinal neuro-degeneration withperipheral nerve conduction in diabetic (type-II) patients.Materials and Methods: A total of 30 diabetic patients age ranging from 35-70 years with mild/moderatenon proliferative diabetic retinopathy (NPDR) and 30 non diabetic control were studied at M.D. eye hospitalPrayagraj R.I.O., Prayagraj. Spectral-Domain -OCT imaging was performed with the cirrus HD-OCT(Version 6.5.0.772; Carl Zeiss Meditec, Inc.), along with nerve conduction study test.Results: Mean ganglion cell inner Plexiform thickness was assessed in diabetic patients with neuropathy(Group-A) and without neuropathy (Group-B) in eyes. The difference between mean thickness of these twogroups was found to be significant at same level of significance and confidence interval (t=4.61, p=0.014).Both the significant difference indicate that diabetic patients with neuropathy (Group A), were associatedwith lower mean of “ganglion cell–inner Plexiform thickness” in both the eyes as compared to withoutneuropathy patients (Group B).Conclusion: In this study we found a positive correlation between decrease in Ganglion cell-innerplexiform layer (GC-IPL) thickness and decrease peripheral nerve conduction in diabetic patients. Decreasein Ganglion cell-inner plexiform layer (GC -IPL) is predictive of early retinal neurodegeneration in diabeticpatients, according to our study.Keywords: Diabetic retinopathy, Electrodiagnostic nerve conduction test GC-IPL thickness, Peripheral neuropathy.

A study to show retinal neurodegeneration association with peripheral nerve conduction in diabetic (Type-II) patients