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Background: Acne is one of the most commonest dermatological disorders in young patients. 1. It is adisease of the pilosebaceous follicular unit. 2. Endocrine mechanisms control the components of sebocytefunction—namely lipid synthesis, proliferation and differentiation. 3. Androgens upregulate the sebaceousglandular function by binding to the nuclear androgen receptors (ARs). Highest density of these androgenreceptors have been demonstrated in sebaceous glands.The mechanisms suggested in acne include: Increased circulating levels of androgens, Increased freeandrogen levels, Increased local metabolism of androgens in skin and increased tissue sensitivity toandrogens.Materials and Methods: This case control study was conducted In the department of dermatology,venerology and leprosy, shadan institute of medical sciences, Hyderabad from February 2019-february-2020. A total of 50 patients (25 males and 25 females) of moderate to severe acne vulgaris resistant toconventional treatment were included in the study A total of 50 patients (25 males and 25 females) ofmoderate to severe acne vulgaris resistant to conventional treatment were included in the studyInclusion criteria: Age range: 14 to 35 yearsExclusion criteria: patients who were receiving any systemic drugs, oral contraceptives or hormonaltherapy, pregnant and lactating. 50 age and sex matched healthy acne free subjects were also part of thestudy.Methods: Venous blood samples were collected for the assay of serum testosterone,dehydroepiandrosterone-sulfate (DHEA-S) and androstenedione (A4A) between 0800-0900 hours.For testosterone assay three samples were collected at 20 minute intervals and pooled together.Immediately after collection the red cells were separated and the sera were stored at - 20?C till assay. Infemales, the samples were collected only in the first half of the follicular phase of the menstrual cycle. Allhormones were measured by radioimmunoassay using standard techniques wi

Correlation of levels of serum testosterone and dhea-s in patients of acne vulgaris