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Scabies has been a major health problem in many countries worldwide because of its veryhigh prevalence. The estimated prevalence varies from 0.2 to 71%. Nearly hundred million people areaffected worldwide. Scabies remains a major problem in terms of its contagious nature and the secondaryinfections which occur as a result of the disease.Aims: To compare the efficacy of Topical Ivermectin and other scabicidal agents. To assess theimprovement in severity of pruritus and severity of lesions.Materials and Methods: This was an prospective and comparative study conducted in dermatology OPDof Madras Medical College, a tertiary care centre in south India between Oct ’ 2015 and Aug’ 2016. About90 clinically diagnosed Scabies cases were randomly segregated into three factions [Group G (GBHC) =30 cases of scabies treated with 1% GBHC lotion, Group P (Permethrin) = 30 cases of scabies treated with5% Permethrin cream and Group I (Ivermectin) = 30 cases of scabies treated with 0.5% Ivermectin cream.Patients response to treatment was followed up with severity of pruritus score and severity of lesions scoreat baseline, third and sixth week of treatment. Based on the assessment of these scores, the response totreatment was categorized into good, moderate and poor. Data was compiled and analyzed with the help ofStatistical Package for Social Science (SPSS).Results: Mean age of the study population was 27.66 years. Forty seven subjects were males (52.2%) andforty three subjects were females (47.8%). In Group I (Ivermectin ) , 86.6%(26 out of 30 cases) had goodresponse to treatment when compared to Group P (Permethrin) 36.7% (11 out of 30 cases) and Group G(GBHC) 10%(3 out of 30 cases). Group I (Ivermectin ) compared favorably to the other two drugs withnearly more than three fourth of the cases having significant improvement at an earlier stage while GroupP (Permethrin) showed better response after twice application when compared to Group G (GBHC)

A prospective and comparative study of efficacy of topical ivermectin to other scabicidal agents in Tertiary care center in South India