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Background: Thyroid peroxidase (TPO) enzyme is required for the synthesis of thyroid hormones. Anyalteration in TPO results in a deranged thyroid profile. Antibodies against TPO serve as useful markers forthe detection of auto-immune thyroid diseases. Thus, present study was conducted to analyse the relationof anti-TPO antibodies with thyroid dysfunction.Materials and Methods: After obtaining an ethical approval, this cross-sectional study was carried out fora period of 2 years. Adult patients (18 years old) presenting with symptoms related to thyroid dysfunctionand referred for analysis of T3, T4, TSH and anti-TPO antibodies were included in the study. Over nightfasting blood samples were collected, labelled and stored. Anti-TPO antibody test for human IgG wasdone using Enzyme Linked Immunosorbent Assay (ELISA) kit. Statistical analysis was carried out usingSPSS (version 26.0). Chi square test was used to compare the data and p-value statistically significant.Results: Total 100 patients were analyzed. Maximum 32 patients were found in 21-30 year age group.Mean age for females was 33.7 1.20 years. Male: female ratio was 1: 2.12. Hypothyroid was noted inmaximum 73 patients with 49 females and 24 males. Positive anti-TPO antibody patients were 44 out ofwhich 33 were females. Almost 35 out of 44 patients were anti-TPO antibody positive and hypothyroid withmajority 27 females. Maximum12 out of 27 hypothyroid and anti-TPO antibody positive females belongedto 21-30 year age group.Conclusion: Anti-TPO antibodies were found to be associated with hypothyroid dysfunction. It was notedmore among females of reproductive age group.Keywords: Anti-TPO antibodies, Females, Hypothyroid, Thyroid peroxidase enzyme.

A study on relationship between thyroid peroxidase antibodies (Anti-TPO antibodies) and thyroid dysfunction patients