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Background: Thalassemic patients live a prolonged life in the light of breakthrough of treatment optionsand early diagnosis, and therefore it is a matter of interest and importance to have a successful reproductiveoutcome in such patients. Having a child is the dream and readiness of being pregnant is the inclination ofnot only Thalassemia intermedia patients but also females suffering from Thalassemia major. Thalassemiais an incurable disease till now and producing thalassemia children only enhances the disease burdenboth for the society and family. This augments the need of successful and early screening thalassemicpregnancies and counseling them for the possible outcomes.Materials and Methods: The present study was conducted in 460 pregnant Females attending OPD ofSGRDIMSAR, Sri Amritsar. Samples were taken after informed consent and processed for Complete BloodCount and Hemoglobin Fractionation using HPLC by Borad.Results: Most of the females had hemoglobin levels between 9-10 g % forming 41.3% of the total females(Table 1). Out of 460 patients enrolled in the study, 21 Females were found to have hemoglobin variants onscreening amounting the prevalence of carrier states to 4.53% (Table 3).Conclusion: All pregnant females should be screened for thalassemia carriers in early antenatal period andpositive patients should have screening of the partner along with relevant counseling regarding treatmentoptions. Cost effective diagnostic options should be made available in the periphery for mass screening.Keywords: Pregnancy, Thalassemia carriers, Thalassemia screening, HPLC, Red cell indices.

Screening of Thalassemia in pregnant females visitng tertiary hospital in Amritsar