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Ckd is rapidly raising epidemic with increasing prevalence in India due to raised diabtes and hypertensioncases. This is a Prospective crosssectional study & proven cases of Ckd (n = 100) admitted in thehospital between March 2014- August 2015. at Gandhi Hospital were included in the study. Serumcreatinine was measured by Jaffe’s and creatininase-creatininase methods and gfr was calculated usingconventional formula and Cockcroft-gault formula. 100 patients were selected with male predominance(1.5:1) and average mean age group of 5th to 6th decade are the Ckd cases.This study established that theclearance measured by 24-hour urine collection has inherent errors, and determined that the CGF formulaproduces better results closest to the clinical symptoms and condition of chronic kidney disease, than thecreatinine clearance obtained with conventional method (i.e., 24-hour urine collection) in patients, statingthat creatinine clearance obtained by using enzymatic creatinine method with COCKCROFT –GAULTformula correlates better.Keywords: Chronic kidney disease, Jaffe’s fixed kinetic method, Enzymatic method, Measured creatinine clearance, Cockcroft-gault method.

international journal of clinical biochemistry and research

Comparative study of glomerular filtration rate estimatation by formulae using two different methods for creatinine estimation in chronic kidney disease