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High doses of radiation therapy are used to destroy cancer cells, these high doses of radiations also damagehealthy cells and tissues near the treatment area or whole body. At present, major advances of radiationtherapy have made it more precise, leading to fewer side effects. The side effects often start duringsecond week of radiation treatment So it is necessary to minimize these side effects with natural availablemedication. Previous studies shown that, 2- deoxy D- glucose, an analogue of glucose and glycolyticinhibitor, enhances radiation induced damage, selectively in tumour cells while protecting normal cellssuggest that 2- deoxy D- glucose can be used as a differential radio modifier to improve the efficacy ofradiotherapy and also it is shown that antioxidant medicinal plants like vitis Vinifera, camellia Sinensis,and zingiber officinale have shown protective effect against radiation induced damage in previous studies.So in the present study, we have selected these antioxidant medicinal plant extracts combines with 2- deoxyD- glucose as a treatment, before and after radiation therapy and measured the levels of nitric oxide, lipidperoxidation and antioxidant enzymes like superoxide dismutase, catalase and glutathione peroxidase intissues like blood, liver, kidney and brain tissues of mice after completion of study. In the present study, itis found that the highest effect is found in a group of animals which are on combination of normal diet andfeeding of deoxy – D glucose with grape seed extract, green tea extract and ginger extract in proportion of1:1:1, in this group of animal’s radiation induced micronucleus formation, formation of metamyelocytesand dysplastic myeloid series cells formation is also found significantly decreased.Keywords: NO- Nitric oxide, TBARS- Thiobarbituric acid Reactive, Substances, SOD- Super oxide dismutase CATCatalase & GPx- Glutathione peroxidase

international journal of clinical biochemistry and research

Radiotherapy Radio protective effect of 2- deoxy D-glucose with combination of selective antioxidant medicinal plant Vitis vinifera, Camellia sinensis, and Zingiber officinale extracts in mice