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24 hours traditional urine collection method is cumbersome and tedious process with lesspatient compliance. Our study proposes a novel fractional urine collection method for protein estimationthat would entail collection of small volumes of urine each time patient voids Over 24h Period. Our aimwas to compare urine protein in proposed method versus traditional 24hour sampling method.Materials and Methods: Cross-sectional, prospective study was a collaborative work betweenDepartments of Nephrology and Biochemistry in our tertiary care hospital. Volunteers (48) and ChronicKidney disease subjects (52) were recruited. Out of which, 76 subjects were selected. Novel methodwas compared with conventional method in each of these groups, before and after centrifugation and withand without preservative. Intraclass correlation coefficient (ICC) and Bland Altman analysis was used toevaluate for agreement between the two methods.Results: All the values were combined without categorization into subgroups. Fractional urine collectionmethod (before centrifugation) without preservative (F1) and with preservative (F2) was compared toconventional method, ICC was 0.93 (C.I, 0.9 to 0.95) and 0.96 (C.I, 0.94 to 0.97) respectively. Aftercentrifugation, fractional urine collection method for F1and F2 versus conventional method, ICC was 0.95(C.I, 0.92 to 0.97) and 0.91 (C.I, 0.86 to 0.94) respectively.Conclusions: The novel collection method is comparable and reliable as traditional 24-hour method. Theuse of thymol as preservative leads to negative interference and centrifugation is mandatory before urineanalysis. With proper sampling, urine protein by novel method has a good agreement with the conventionaltechnique.Keywords: Factional, Urine protein, Traditional 24h urine, Urine creatinine.

A pilot study to compare urinary protein of fractional urine collected over 24h period versus traditional 24h urine collection method