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Purpose of the study: The high prevalence of diabetes in the rural population of India required an early andaccurate diagnostic tool. There were several techniques standardized and recommended by the AmericanDiabetes Association. Some of the techniques were plasma glucose, oral glucose tolerance test, and HbA1c.The efficacy of HbA1c is questionable in individuals having a low haemoglobin content. This situation isfurther aggravated due to high anaemic individuals in rural population. This study was therefore designedfor analyzing the efficacy of HbA1c in diagnosing diabetes in anaemic individuals.Brief description of the experiment: The experiment involves the enrolment of individuals who arediabetic. Further, these individuals were divided into anaemic and non-anaemic individuals. Here, anaemicindividuals were termed as cases and non-anaemic individuals were termed as controls. Samples werecollected from both the cases and controls and analyzed for fasting plasma glucose, serum iron and directTIBC, HbA1c levels, and oral glucose tolerance test.Results: The results obtained in this study shows that the HbA1c levels were lower in the anaemicindividuals as compared to the non-anaemic diabetic individuals. There was a positive correlation betweenHb level and HbA1c level in an individual, thus indicating that an increase in the Hb level will cause anincrease in the HbA1c level in diabetic individuals.Conclusion: The study provides a baseline that HbA1c can’t be considered as a reliable tool for diagnosingdiabetes in anaemic individuals. Further extensive studies are required to strengthen these findings withrespect to a larger population.Keywords: Diabetes, HbA1c, Anaemia, Iron, Haemoglobin.

Is HbA1c a reliable diagnostic marker for diabetes mellitus in patients with iron deficiency anaemia?: A cross sectional study