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Background: An effective β-catenin/Transcription Factor 7 Like 2(TCF7L2) axis is essential in transcription of Proglucagon gene for synthesis of GLP-1. It upholds β-cell health, augments glucose-dependent insulin processing, secretion and also suppression of postprandial glucagon secretion.TCF7L2 gene polymorphism at rs7903146 and rs12255372 which are in strong linkage disequilibrium with microsatelite DG 10S478 had shown robust association with T2DM in various population. Hence we aimed to study association between TCF7L2 gene polymorphism and T2DM among Chennai suburban population. Materials and Methods: This case–control study included 44 T2DM cases with 44 age and gender matched healthy controls. Genotyping done by Restriction Fragment Length Polymorphism- Polymerase Chain Reaction for rs7903146(C/T) and by Allele specific Amplification Refractory Mutation System for rs12255372(G/T).By Hardy-Weinberg law, frequency of genotype distribution were compared using Chi-square (?2) test.  Result: At rs7903146 (C/T),T allele frequency was significantly higher in diabetic group(30.7%) than control group(2.0%) with odds ratio of 0.19(95% CI 0.04-0.83, p Conclusion: Our finding support that as in many ethnic groups, the TCF7L2 gene polymorphism at rs7903146 (C/T) could be an important genetic risk factor for T2DM in Chennai suburban population.  Keywords: Type 2 diabetes, Transcription factor 7-like 2 (TCF7L2), Glucogon like peptide-1(GLP-1), Insulin, Restriction Fragment Length Polymorphism (RFLP), Allele specific Amplification Refractory Mutation System (ARMS- PCR).

Association of variants of the TCF7L2 gene at rs7903146(C/T) and rs12255372(G/T) with type 2 diabetes mellitus in Chennai suburban population