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Background: The left atrium possess a venous component, a vestibule and an appendage and shares theseptum. The structure of the heart undergoes constant adaptation to physiologic changes in the organism.LAA is a major endocrine organ and is the main producer of ANP (atrial natriuretic peptide) in the humanheart. Atrial cardiocytes of the mammalian heart contain granules which are morphologically similar tothose in peptide secreting endocrine cells. The cardiocytes of LAA contain the greatest density of ANFgranules found in Left Atrium and it is therefore of interest to carry out further studies on these granules. 1Aims: Looking to the great clinical significance that is given to the morphology of LAA & itspredilection as a site for thrombus formation, we’ve conducted a detailed study histologically of LAA.To investigate LAA and study the arrangement of muscle bundles of LAA histologically (with a specialstain-Masson’trichome) and these findings were co-related with that described in the literature.Materials & Methods: The materials for the present study were collected from the Department ofAnatomy & Forensic medicine of Sri Aurobindo Medical College and Post Graduate Institute, Indore.Randomly five hearts were selected and slides of LAA from different sites (apex, inferior margin and atrioauricularjunction) were prepared by routine Histological Techniques and stained by Haematoxylin &eosinand Masson’s trichome(special stain)Conclusion: This study of its histological features is an attempt to establish the cause of variouspathologies related to arrythmias.Keywords: LAA(Left atrial appendage), ANF(Atrial natriuretic factor), Histologically.

Histological aspect of left atrial appendage (LAA) with special stain-masson’s trichome