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Digit ratio or 2D:4D ratio is a sexually dimorphic trait. It is a proxy marker of prenatal androgen exposure and is negatively correlated to prenatal androgens especially, testosterone. Literature search revealed significant correlations between digit ratios and various physiological, psychological or performance traits in adulthood. Objectives: The pilot study was conducted to measure 2D:4D ratios of patients with Major Depressive Disorder (MDD) and to compare it with normal (non-depressed) individuals and also to evaluate the correlation between digit ratios & depression scores. Materials and Methods: The present study was conducted in adults of age group belonging to 25-40 years with MDD (Group 1: n=30), from a tertiary care centre for Psychiatry. Using digital vernier calipers 2D:4D ratio was measured. Diagnosis of depression was done by the psychiatrist using DSM –IV criteria and depression scores were calculated by Hamilton depression rating scale (HDRS). Depression scores using Beck’s Depression Inventory and digit ratios were measured in age and sex matched healthy controls (Group 2: n=30). Results: The Mean ratios of Group 1 (0.9659 ± 0.04161) was found to be lower than Group 2 (0.9788 ± 0.0371). Using standard cutoffs, Group 1 was divided into Low and High digit ratios. The proportion of Group 1 patients with high ratios (84%) was significantly more than those with than low ratios (16%) (p<0.001). Discussion: The outcomes of the present study were synchronous with reports of higher incidence of depression in females, nationally and globally. This was concurrent with the other reports of the previous studies. This would help us to conduct the future studies even on large study population. © 2019 Published by Innovative Publication.

Measurement of 2D:4D ratios in patients with major depressive disorders: A pilot study