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Aims: Study aims to reduce the emergence agitation post operatively and improve the quality of recoveryafter nasal surgery which in-turn reduce the hospital stay and in-hospital mortality.Settings and Design: Prospective, randomized, double blind studyMaterial and Methods: After institutional review board approval and informed written consent frompatients, seventy patients undergoing nasal surgery were selected & randomized into two groups. Thedexmedetomidine group (Group D, n=35) received dexmedetomidine infusion @ rate of 0.4 mg/kg/hrfrom induction of anaesthesia until extubation, while the control group (Group C, n=35) received volumematchednormal saline infusion as placebo. Induction of anaesthesia was done using Propofol (2 mg/kg) andfentanyl (1 mg/kg). Maintainance of anaesthesia was done using inhalational sevoflurane & inj.vecuronium.The incidence of agitation, haemodynamic parameters, and recovery characteristics were evaluated duringemergence. Patients were assessed for quality of recovery using a 15-item quality-of-recovery questionnaire(QoR-15) 24 hr after surgery.Statistical Analysis: Data were analysed by using unpaired t -test, Chi-square test.Results: The incidence of agitation was lower in group D than group C(22.8% vs 51%). HR and MAPwere comparable in group D & group C. Extubation time & grade of cough during emergence were similarbetween the groups. QoR-15 score was significantly more in group D compare to group C at 24 hour aftersurgery.Conclusions: Intraoperative infusion of dexmedetomidine decreased incidence of agitation & improvedquality of recovery after nasal surgery.

indian journal of clinical anaesthesia

Role of dexmedetomidine infusion on post operative emergence agitation and quality of recovery after nasal surgery: A prospective randomized double blind controlled trial