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Hypotension is most common intraoperative complication after spinal anesthesia duringcesarean delivery. The Bezold–Jarisch reflex is one of the causes for occurrence of hypotension after spinalanesthesia through serotonin with decreased blood volume. Our aim of this study was to compare the twoserotonin receptor antagonists Ondansetron and Granisetron to prevent spinal induced hypotension andbradycardia after spinal anesthesia in parturients undergoing cesarean sections.Materials and Methods: 90 patients of ASA class-I and II, aged 20-40years, weight 40-80kilograms wereincluded in this study. Patient with history of PIH, convulsion, any major comorbidity were excluded fromstudy. Patients were assigned into 3 groups group A received 4 mg Ondansetron intravenously, group Breceived 1 mg Granisetron intravenously and group C received 10 ml of intravenous normal saline 5 minbefore spinal anaesthesia. The difference in mean was analyzed using post hoc Bonferroni test and ANOVAtest. The difference in proportions was analyzed by using chi-square test.Results: SBP, DBP and MBP were statistically lower in both Granisetron and Saline group as compared toOndansetron group at most of the times after drug administration. Heart rate and shivering were comparablein the three groups. Nausea and vomiting was statistically more in saline group as compared to other groups.Use of ephedrine was also significantly more in saline group (37%).Conclusion: 4mg intravenous Ondansetron prior to spinal anaesthesia in LSCS patients reducesthe incidence of hypotension, bradycardia and need of vasopressor. Granisetron had no effect onhaemodynamic parameters.Keywords: Hypotension, Ondensetron, Granisetron, Bezold jarisch reflex, Spinal anesthesia, Bupivacaine.

indian journal of clinical anaesthesia

A comparative study between intravenous Ondansetron and Granisetron in attenuation of hypotension during spinal anaesthesia in patients undergoing caesarean section