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Pre-emptive analgesia is - blockade of afferent nerve fiber before surgical stimulus. Preemptiveanalgesia reduces the physiological consequences of nociceptive transmission provoked by theprocedure. Pre-emptive analgesia has the potential to be more effective than a similar analgesic treatmentinitiated after surgery. Consequently, immediate postoperative pain may be reduced and the developmentof chronic pain may be prevented. Aim of this study was to evaluate the efficacy of preemptive Pregabalinand Paracetamol and comparison between the two.Materials and Methods: 120 patients of ASA class 1 and 2 scheduled for lower limb surgeries underspinal anaesthesia were randomly allocated into two groups of 60 each, Group PG received Pregabalin150 mg & group PA received 1gm Paracetamol, 1 hour before surgeries respectively, Spinal anaesthesiatechnique was standardized to all patients. Post operative pain was assessed using VAS at 2, 4, 6, 12, 24hours after surgery. If VAS more than 3, rescue analgesia was given as Inj. Tramadol 1mg/kg. Time of firstrescue analgesic & total amount of analgesic over 24 hours noted.Results: Mean VAS for group PG at 2, 4, 6, 12, and 24 hours after surgery was lower compared to thegroup PA. Time of first rescue analgesia (4.31.2 hrs PG vs 3.31.1 Hrs PA) and total number of rescueanalgesia for 24 hours period post operatively was significantly lesser for group PG compared to PA.Conclusion: Pre-operative administration of oral Pregabalin 150mg was an effective adjuvant for acutepain after surgery compared to oral Paracetamol 1000mg.Keywords: Pre-emptive analgesia, Pregabalin, Paracetamol, Postoperative pain, Visual analogue score, Tramadol, Rescue analgesia.

indian journal of clinical anaesthesia

Comparison of efficacy of oral pregabalin and oral paracetamol as pre-emptive analgesics in patients receiving spinal anaesthesia for lower limb surgeries