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Introduction & Aims: Intraoperative motor evoked potential monitoring is commonly used during spinalsurgeries as it reduces incidence of neurological damage and have better post-operative neurologicaloutcome.Anaesthetic agents cause a dose dependent inhibition of evoked potential responses while ketamineand dexmedetomidine are said to have minimal effect. We planned this study to compare effect ofdexmedetomidine and ketamine on MEP.Materials and Methods: All patients induced using glycopyrrolate, fentanyl, propofol and no anxiolyticsand intubated with succinylcholine 2mg /kg, maintenance done with propofol infusion@ 60 mg/hr inboth groups. Group-D- received dexmedetomidine 0.5mg/kg and Group-K- received ketamine 0.6mg/kgin 100ml NS over a period of 10mts.Electrodes were placed above the level of surgical intervention forMEP and TOF recording.Baseline MEP recorded and after completion of infusion of the study drugs was taken as 0 min, then theMEP was recorded at every 5 min till 30 min.Results: In our study we observed that amplitude of MEP was statistically significant (p value 0.009 at 15minutes) and was higher in ketamine group than dexmedetomidine group.Conclusion: We concluded that both agents are equally good as they cause minimal depression and areequally efficient in measuring the amplitude of MEP.Keywords: Depressant effect, Dexmedetomidine, Ketamine, Amplitude, MEP, TOF.

Comparison of dexmedetomidine with ketamine for their effects on amplitude of motor evoked potential intraoperatively